Methods: I'm 40 years . This can causes problems with interpretation of pregnancy tests done earlier than 14 days after an HCG injection. Patients with low -hCG values are often very anxious about their pregnancy outcomes. A retrospective study was conducted at the Third Affiliated Hospital of Guangzhou Medical University to study patients whose serum -hCG levels were at 5299 mIU/ml 14days after frozen blastocyst transfer. If you are worried or anxious about your pregnancy test, call our Fertility Nurses or our Fertility Support Midwife, who provide valued support and early pregnancy advice during the 'two week wait'. This prospective study was designed to assess the predictive value of a 14-day post-ET hCG level with pregnancy outcome and multiple gestation pregnancies. Ultimately you're going to have to wait for that first ultrasound (which probably feels forever away)but your post makes it sound as though you would be excited about having multiples, so fingers crossed that it works out for you. For patients without follicular development, an artificial cycle was given. Please select a reason for escalating this post to the WTE moderators: Connect with our community members by starting a discussion. A Chi-squared test was used to compare rates. Congratulations on your pregnancy. They illustrated that the -t2 on day 12 after embryo transfer was about 1.6days and the cut-off value of 2.2days had an optimal PPV of 87% and an NPV of 42% [11]. Epub 2017 Oct 16. And finally, no vanishing twin syndrome occurred in the setting of a twin pregnancy, with the notable exception of 14 total miscarriages. It is routine to have serum -hCG tests conducted 914days after embryo transfer to confirm the diagnosis of pregnancy. Wu, Y., Liu, H. Possibility of live birth in patients with low serum -hCG 14days after blastocyst transfer. 2016 May 20;(5):CD011537. Fertimed, Fertility Treatment Centre, Olomouc. YXW designed research and wrote the manuscript. \). If the level was less than 300, the ongoing multiple pregnancy rate was 9% (5/57). Sung N, Kwak-Kim J, Koo HS, Yang KM. Everyone is different and Hcg loves aren't a good indicator of twins-you need an ultrasound to know for sure. J Reprod Med. 3 weeks LMP: 5 - 50 mIU/mL. Necessary cookies are absolutely essential for the website to function properly. Clipboard, Search History, and several other advanced features are temporarily unavailable. The sensitivity of the assay was 1.2 mIU/ml, with an intra-assay coefficient of variation of 7%. MeSH Is there an optimal range for every week progressing ? An hCG level under 5 is considered negative. Correspondence to You may find out you have one crazy pile of hormone releasing singleton. But if you experience vomiting or nausea during these two weeks . If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. Fertil Steril. Our study demonstrated that the initial -hCG value >58.8 mIU/ml predicted 85.8% of clinical pregnancies, while a failure to achieve that value led to 73.3% of biochemical pregnancy loss. The patients age was not proven to be of significant influence, the hCG level slightly decreased with higher age. Roughly. The beta hCG. Accessibility At this point, if the embryo has implanted, you will also get a positive urine pregnancy test. Results: One thousand three hundred forty cycles involving a single embryo were analyzed. I've been on endomentrin since before fet. Find advice, support and good company (and some stuff just for fun). Had to wait until my ultrasound to confirm it was twins. Privacy Fertil Steril. It is important to determine beta-hCG levels regardless a potential bleeding since bleeding can occur during early pregnancy. Fertil Steril. tive value of - hCG levels following a day 5 embryo transfer in comparison to predictive values after a day 3 embryo transfer. The site is secure. HCG0 was defined as serum -hCG concentrations that were measured 14days after embryo transfer; HCG1 was defined as serum -hCG levels in the second test, and the term days represented the interval between the two -hCG tests. I guess 5 weeks is for the natural conception. This article did not contain any studies with animals performed by any of the authors. Beta hCG levels are trustable 15 days after the ET. If it's doubling, then it means that everything is going as expected. Fertil Steril. Stone et al., investigated the association between the doubling time of serum-borne -hCG (-t2) and ongoing pregnancy in pregnant women after assisted reproductive technology (ART). TTC #1 since 8/1/10; Me:41 and BRCA1+, DH:46 Subsequently, i only had one baby. Whats the opinion of your doctor? The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. About ten to 14 days after an embryo transfer, you will go back to your clinic for a blood pregnancy test (aka "beta", "beta hCG", or "-hCG"). new2ivf_Boston likes this Twin girls born December 2017 after 7 years of TTC See 'About Me' for full details #5 CrisBelieve 1000+ 1651 posts Gender: Female Thanks for your reply. What is Assisted Reproductive Technology? Yet, they tend to decrease after the three month mark. I'm afraid it is a negative result indeed. I didn't. Check this chart to learn more about normal beta hCG levels during pregnancy: Normal hCG levels in pregnancy chart. Not sure this information really helps you out as I know everyone is different. Second, the number of embryos that were successfully transferred varied from one to two. Serum hCG-beta levels of postovulatory day 12 and 14 with the sequential application of hCG-beta fold change significantly increased predictability of pregnancy outcome after IVF-ET cycle. 4 weeks LMP: 5 - 426 mIU/mL. Normally, you do your first pregnancy test (HCG blood test) 14 days after embryo transfer. The present research possesses the following advantages. Informed consent was obtained from all individual participants included in the study. In addition, for patients having an initial -hCG >58.8 mIU/ml, then continued luteal phase support is strongly indicated. Serum hCG values for viable and non-viable pregnancies were compared by Student's t test. 2. When this happens, a woman's body begins to produce the pregnancy hormone (hCG) from cells in the developing placenta. 2021 Jul;28(7):1827-1838. doi: 10.1007/s43032-020-00347-8. Human chorionic gonadotropin (hCG) is a hormone that is released by the human embryo after conception. Logarithmic curves depicting initial level and rise of serum beta human chorionic gonadotropin and live delivery outcomes with in vitro fertilization: an analysis of 6021 pregnancies. Please specify a reason for deleting this reply from the community. However, the serum -hCG levels of patients with live births (median: 196 mIU/ml) was significantly higher than that of patients with non-live births (median: 140 mIU/ml, P=0.0001; Table3). Used to limit the percentage of requests. Analytical cookies are used to understand how visitors interact with the website. This Cookie is set by the GDPR plugin and is used to store whether or not the user has consented to the use of Cookies. More information on the. Below 1,200 mIU/ml, hCG usually doubles every 48-72 hours, but 35%+ is still normal. This study sought to investigate pregnancy outcomes of patients with an initially low serum -hCG level at 14days after frozen blastocyst transfer. It's produced by your placenta after conception. I am also 43, I had one 5 day frozen transfer almost 25 weeks ago. Statistical analysis was performed using a mixed effects model and the Bayes classifier. Department of Obstetrics and Gynecology, Center for Reproductive Medicine/Department of Fetal Medicine and Prenatal Diagnosis/BioResource Research Center, Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China, Key Laboratory of Reproductive Medicine of Guangdong Province, No. Group Leaders arent expected to spend any additional time in the community, and are not held to a set schedule. PubMed JBRA Assist Reprod. You will probably get a lot of responses about checking the posts at the top of the page because they remind people that hormone levels are not an indication of a pregnancy with multiples. Cells that eventually become the placenta and fetus have begun to develop. Cycles where women underwent IVF with subsequent autologous fresh or frozen embryo transfer (ET), had a serum hCG >5 mIU/mL 8 or 10 days after ET, and had an US performed between 5 0/7 and 6 6/7 weeks that did not demonstrate a viable multiple gestation . CVS is a diagnostic test so it is more accurate but carries about a ..5% risk of miscarriage (1/200). Reddit and its partners use cookies and similar technologies to provide you with a better experience. Article The threshold for live birth was 1.9 with an AUC of 0.808, a sensitivity of 88.5% and specificity of 64.5%. Then I didn't even get anymore blood work. When do you find out for sure? . Anyone else who has /had similar experience? I did CVS with my only child who is nearly 3 yrs. The study was approved by the local Ethics Committee of the Third Affiliated Hospital of Guangzhou Medical University. 1993 May;59(5):1081-9. doi: 10.1016/s0015-0282(16)55932-9. This study was supported by the National Natural Science Foundation of China (No.81801532, to HYL and No.81701518, to YY) and Scientific Research Program of The Third Affiliated Hospital of Guangzhou Medical University (No.2017Q15, to YXW). In addition, they are often required to take serum -hCG tests in order to monitor the progress of conception, which will increase the number of visits and thus bring them both psychological and economic stress. I am currently 23 w tomorrow with twins. Location: Ryan Family Atrium, Robert H. Lurie Medical Research Center . government site. The gynae said "tentative congratulations" and also said that it may be just to early to see anything in the second sack but likely not twins. ktberry, your levels were 2/3 mine. official website and that any information you provide is encrypted It can take up to a couple of weeks from transfer day until the placenta cells start producing enough of the hormone known as human chorionic gonadotropin (hCG) to be detected by a blood. The beta hCG quantitative blood test is ordered 14 days after your egg retrieval. You'll have to wait until the ultrasound to find out. hCG levels chart in weeks from DPO (days past ovulation): 1 week DPO: 5 - 50 mIU/ml 2 weeks DPO: 5 - 426 mIU/ml 3 weeks DPO: 18 - 7,340 mIU/ml 4 weeks DPO: 1,080 - 56,500 mIU/ml 5 - 6 weeks DPO: 7, 650 - 229,000 mIU/ml 7 - 10 weeks DPO: 25,700 - 288,000 mIU/ml 11 - 14 weeks DPO: 13,300 - 254,000 mIU/ml 15 - 22 weeks DPO: 4,060 - 165,400 mIU/ml For the -hCG fold increase over 48h, the cut-off for clinical pregnancy was 1.4 with an AUC of 0.899, a sensitivity of 90.3% and a specificity of 77.8%. To keep all these cookies active, click the Accept button. The thresholds predicting clinical pregnancy and live births in these studies were higher than those in our study, which can be explained by the fact than only patients with a low -hCG were included in our research. First, we only analyzed patients with low serum -hCG levels instead of investigating all pregnant patients, which will be helpful in developing appropriate suggestions of follow-up for this group of patients. It does not store any personal data. If the hCG level was greater than 600, the multiple pregnancy rate was 100% (7/7). Congrats!! So there will not be a heart beat yet. After 5 years of trying to conceive without any success, My husband and I had decided to try IVF and we were very lucky to success on the first try. Early miscarriage was defined as fetal growth arrest or no cardiac activity that was detected in the gestational sac during the first 12weeks of pregnancy. Our study showed that pregnancy outcomes of the patients with initially low serum -hCG levels were poor, with only 18.6% of live births. If the initial serum -hCG is <58.8 mIU/ml, it is suggested that luteal phase support is discontinued and measurement of serum -hCG and ultrasound can be arranged one week later, since no live births occurred in this group of patients. I had 460 @ 10dpt, 3500 @ 14dpt and was twins. Our study showed that pregnancy outcomes of the patients with initially low serum -hCG levels were poor, with only 18.6% of live births. Fishers exact test was applied when the expected count was <5 or the total sample size was <40. It typically takes 48-72 hours after the embryo transfer for the embryo to implant. Although many previous studies have investigated the prediction of pregnancy outcomes by measuring serum -hCG levels after blastocyst transfer, no study has yet focused on pregnancy outcomes of patients with an initially low serum -hCG level. Has anyone needed more HCG on top of progesterone at this stage? Your levels are almost identical to mine. I had an ultrasound on 14th, they didnt see any yolk, just a tiny sac and also they confirmed that there was no ectopic pregnancy. Since it is detected in maternal serum as soon as 68days after fertilization, -hCG is widely used in the clinic as a marker of pregnancy. Vaginal progesterone (Crinone, Merck Serono, Germany 90mg qd) was given for luteal phase support in artificial cycles. I "pray" that both my little babies do well. It reaches its peak by 8-11 weeks of pregnancy and levels off. First, the patients studied had a -hCG test 14days after embryo transfer. Reprod BioMed Online. Hum Reprod. Predictive value of initial serum human chorionic gonadotropin levels for pregnancies after single fresh and frozen blastocyst transfer. If positive, serial values of hCG were obtained and transvaginal ultrasound was performed 3 weeks after ET and weekly until fetal cardiac activity was seen. 5. In the present study, pregnancy outcomes of patients whose serum -hCG levels were < 300 mIU/ml 14 days after blastocyst transfer were investigated. Bookshelf Our previous study investigated the likelihood of live births with serum levels of -hCG <100 mIU/ml 14days after day 3 embryo transfer, which showed that the live birth rate was only 4.3%. My doctor has no idea what it could have been. It has been reported that the quantitative serum hCG level 14 days after embryo transfer (ET) correlated with pregnancy outcome as well as a likelihood of a multiple gestation pregnancy. Then i start having cramps which are very much like my menses cramps with on n off headaches. I was told by my clinic that the "doubling" time is more significant than the numbers. For frozen embryo transfer, the cut-off value was 137399IU/L for clinical pregnancy and 212411IU/L for live births 1112days after embryo transfer [6,7,8]. Certified by Health Quality Agency of Andalusia, Certified Medical Website by the Official College of Physicians of Barcelona, Confianza Online seal of quality and transparency, Busines Adapter certificate in compliance with the LSSI (Spanish Information Society Services Act). Zhang X, Barnes R, Confino E, Milad M, Puscheck E, Kazer RR. My main concern is that high HCG levels early on can be something of concern. My Hcg 10dp5dt (2 embryos) was 551. One hundred eleven patients had positive serum quantitative hCG levels 14 days post-ET; 89/111, or 80.2%, had ongoing pregnancies. A Group Owner is a member that has initiated the creation of a group to connect with other members to share their journey through the same pregnancy & baby stages. However, this time around I am quite afraid of doing CVS. Epub 2020 Oct 9. Results: Incidence of viable pregnancies in B-hCG levels less than 100 IU/L (n=18) was 38.9%, and in B-hCG levels more than or equal to 100 IU/L (n=79) was 84.4% . I read others beta levels and I think that mine are extremely low. For natural and stimulatory cycles, vaginal progesterone gels (Utrogestan, Besins Healthcare, France, 200mg bid) was used to support the luteal phase. Hello! Sammipacheco11. I feel more at ease. Possibility of live birth in patients with low serum -hCG 14days after blastocyst transfer, \( {\left(\frac{\mathrm{HCG}1}{\mathrm{HCG}0}\right)}^{\raisebox{1ex}{$2$}\!\left/ \!\raisebox{-1ex}{$\mathrm{days}$}\right.} The threshold for live births was 108.6 mIU/ml with an AUC of 0.649 (95% CI: 0.0.5830.715), a sensitivity of 93.1%, and a specificity of 37.0% (Fig. In the present research, the rate of a twin pregnancy was only 5.1% (16/312) with an initial serum -hCG level<300 mIU/ml. National Library of Medicine I had it done at Cedar Sinai with Dr. Williams, who has done about 27,000 CVS procedures and has had good results compared to other clinics. HCG Levels during the first trimester. Once I hear a heartbeat on Tue (crossing my fingers), I will do lots of research on this but what many woman are doing on this board sounds reasonable. And congrats and have a happy healthy pregnancy either way. At my age, I definitely need to screen for abnormalities. My first pregnancy first hcg was 13 days after transfer and i had 2300 level. Initially low serum -hCG levels measured at 14days after frozen blastocyst transfer indicated a minimal likelihood of a live birth. Note that once you confirm, this action cannot be undone. On day 12 following embryo transfer, serum hCG level of each patient was determined by a fluoroimmunometric assay system. What does an hCG level measure? One had a heartbeat of 120 bpm and the other only 110. Statistical analysis was performed with SPSS version 22.0 software (IBM, Armonk, NY, USA). Springer Nature. I was so anxious and was preparing for the worse so I was shocked to hear two heartbeats. The .gov means its official. By accepting all cookies, you agree to our use of cookies to deliver and maintain our services and site, improve the quality of Reddit, personalize Reddit content and advertising, and measure the effectiveness of advertising. 2011 Dec;96(6):1362-6. doi: 10.1016/j.fertnstert.2011.09.042. The data sets used and/or analyzed during the current study are available from the corresponding author on reasonable request. I heard hcg doubles every 48 hours, does this apply to whatever baseline we have? Fold increases in -hCG concentrations over 48h were calculated by the following formula: Fold increase = \( {\left(\frac{\mathrm{HCG}1}{\mathrm{HCG}0}\right)}^{\raisebox{1ex}{$2$}\!\left/ \!\raisebox{-1ex}{$\mathrm{days}$}\right.} I had three 5-day embryos transferred and I had just turned 43 yrs when my eggs were retrieved so it is extremely unlikely that I could be carrying twins or triplets due to the high rate of abnormal embryos in my age group. What should hCG levels be 14 days after embryo transfer? Did you do PGS? My doctor though wants me to have another beta test(!!) I know I need to wait until ultrasound to REALLY know but I'm curious as to others' experiences (so hard to wait!!!). The whole rechecking causes me a lot of stress and agony.. Hello again, Im completely scared to death I had another beta test yesterday, June 16th and the result was 2078. Among the 241 clinical pregnancies, 225 (93.4%) were singletons and 16 (6.6%) were twins (i.e., 9 monozygotic twins and 7 dizygotic twins). 63, Duobao Road, Guangzhou, Guangdong, China, You can also search for this author in MeSH Would you like email updates of new search results? Create an account to follow your favorite communities and start taking part in conversations. An HCG value of 76 IU/l emerged as the most suitable cut-off point to predict viable pregnancy. Thus, our results may only be applicable in predicting patients that had a serum hCG test 14days after blastocyst transfer. Home urine test: Depending on when implantation occurs, pregnancy may be able to be detected in certain early home pregnancy tests as soon as five days after a transfer of a 5-day embryo. Hi there - I just completed my first IVF cycle. What are the most frequent symptoms after an embryo transfer? Beta is in 3 days (1 Feb 2018). Symptoms after embryo transfer during IVF treatment: from personal experience. I was told by my clinic that the doubling time is more significant than the numbers. First u/s show to have 2 embryos, but inly one developing at normal rate. The rates of ongoing pregnancy were comparable between the progesterone supplementation group and the control group whose progesterone level was above the cut-off. The burse said numbers dont provide that info, onlu u/s.so now we just waiting. What a relief it must be to know there are no chromosomal abnormalities. Of course only the ultrasound will tell you for sure but lots of things can happen! 312 patients had serum -hCG levels <300 mIU/ml at 14days after frozen blastocyst transfer, among which, 18.6% were live births, 47.4% were early miscarriages, 22.8% were biochemical pregnancies and 9.6% were ectopic pregnancies. There are other medical reasons that could be behind an unusually high beta hCG. Conclusion: To examine patients after embryo transfer for predictive influence of the human chorionic gonadotropin (hCG) level on the probability of finishing pregnancy with delivery. I was wondering if numbers indicate singleton or twins. 1985 Oct 26;291(6503):1160-3 Good luck! This cookie is set by GDPR Cookie Consent plugin. ROC curve analysis showed that a predicted value of -hCG for clinical pregnancy was 58.8 mIU/ml with an area under the ROC curve (AUC) of 0.752, a sensitivity of 95.0% and specificity of 53.5%. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. They have given me more hcg injections though "to sustain the pregnancy" and another scan in one week. Zhao et al., found that the single -hCG value of 399.5IU/L on day 12 after blastocyst transfer was reliable to predict clinical pregnancy with a PPV of 93.47% and an NPV of 67.61%. Wang Q, Zhang R, Jia M, Luo L, Ding C, Li TC, Zhou C. Gynecol Endocrinol. Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. National Library of Medicine 2022 Jan 17;26(1):62-67. doi: 10.5935/1518-0557.20210054. Clinical pregnancy was defined as an intrauterine/extrauterine gestational sac that was detected by ultrasound with positive serum -hCG levels. Generally, hCG maintains progesterone levels during the beginning of pregnancy, which supports healthy uterine and fetal growth. Im so worried and confused. I'd be happy with a healthy singleton. These patients are often in a state of anxiety, and tend to be concerned about the possibility of a poor prognosis. 2. Zhang Q, Yan J, Tang R, Gao X, Zhang B, Chen ZJ. Good luck to you! For that reason the data was analysed through a multinomial logistic model vs. multinomial distribution of a mistake and generalised logistic link function. The measured hCG values are considerably different depending on the pregnancy result, which is why this value is considered a quality predictive factor of the pregnancy result. so this Tuesday I'll be 6 weeks and hoping I will hear a heartbeat. The threshold for live births was 108.6 mIU/ml with an AUC of 0.649, a sensitivity of 93.1% and a specificity of 37.0%. HHS Vulnerability Disclosure, Help 2018 Aug;37(2):208-215. doi: 10.1016/j.rbmo.2018.04.048. The rate of live birth was 24.9% (56/225) in singletons and 12.5% (2/16) in twins. In some IVF cycles, fresh embryos are transferred, while in other cases, frozen embryos can also be transferred to the uterus. The effect of serum -hCG on pregnancy outcomes was explored by logistic regression analysis. Result was negative. Association of early beta-human chorionic gonadotrophin values with pregnancy wastage and multiple implantation in a donor oocyte programme. If you did a frozen embryo transfer: The beta hCG quantitative blood test is ordered 9-13 days after your embryo transfer, depending on the developmental stage of the embryo when . Are you getting the testing done? Unauthorized use of these marks is strictly prohibited. 1, Table5). If the level was between 300 and 600, the ongoing pregnancy rate . For patients having an initial -hCG >58.8 mIU/ml, luteal phase support should continue. You may very well see 2 babies at your first ultrasound! The possible reasons are as follows: First, the serum -hCG levels in our study were measured 14days after blastocyst transfer, which was at least two days later than that in Sungs research. These data support the hypothesis that hCG levels greater than 200 mIU/ml on 14 days post-ET are more likely to have ongoing pregnancies; hCG levels greater than 600 have a high likelihood of a multiple gestation pregnancy. I agree that the range is wide and that the trend may be more informative. Today is the 12th day after Embryo transfer, i couldnt wait so i bought a Home Pregnancy Kit (which claim it can detect HcG at low levels. Get the IPS Communities App for iPhone now. First HCG level after 14 days of transfer is 964. Happybump43, congrats on your twin pregnancy. -, Fertil Steril. 1986 Apr;45(4):526-31 8600 Rockville Pike Design: Zhao WE, Li YJ, Ou JP, Sun P, Chen WQ, Liang XY. Unable to load your collection due to an error, Unable to load your delegates due to an error. Then the blastocysts were placed into a Cryotop and placed immediately into liquid nitrogen. Biochemical pregnancy loss was defined as a serum -HCG level>5mIU/ml 14days after transferring the embryo, which declined to <5 mIU/ml at the end of pregnancy without a visible gestational sac by ultrasound. Rates of live birth, early miscarriage, biochemical pregnancy loss and ectopic pregnancy were analyzed according to the female patients age by Chi-squared analysis. It is for this reason that most IVF programs will do a first pregnancy test approximately 15 days after the hCG trigger injection (or 13 days after egg retrieval). To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. Prognostic value of beta-human chorionic gonadotropin is dependent on day of embryo transfer during in vitro fertilization. lol congrats :) hope you have a smooth pregnant and please update is either way :). Press question mark to learn the rest of the keyboard shortcuts. 2001;76:9817. What to Expect supports Group Black and its mission to increase greater diversity in media voices and media ownership. Journal of Ovarian Research I will be only 4 weeks post day-5 embryo transfer. Eskandar MA, Al-Shahrani M, Shaamash A, El-Emain M, Al-Ahmad M, Payodon B. J Clin Med Res. 2014;59:28592. The views expressed in community are solely the opinions of participants, and do not reflect those of What to Expect. A good friend transferred 2 embryos and her levels were only in the 500s after 14 days. Here are my results9dpt = 238, 10dpt = 557, 12dpt = 1473. sharing sensitive information, make sure youre on a federal -. sharing sensitive information, make sure youre on a federal Like the others said, there is no real way of knowing as beta levels vary a lot. For these reasons, it is very important to make individualized follow-up plans according to different serum -hCG intervals. For vitrification, the blastocysts were equilibrated in an EquilibrationSolution for 2min and then transferred to a VitrificationSolution, wherein the embryos would remain for 4560s at 37C. Bethesda, MD 20894, Web Policies If the initial serum level of -hCG is <58.8 mIU/ml, then discontinued luteal phase support is suggested and assay of serum -hCG and ultrasound can be arranged one week later. 2015;103:152631 e12. 2009;91:17604. Found out at 6 mos that our little one had died weeks earlier and had to induce and deliver stillborn, July 25, 2013. But many successful pregnancies do start out with a lower beta hCG level. Serum -hCG levels and fold changes in -hCG levels over 48h were applied to predict clinical pregnancy as well as live births by plotting Receiver Operating Characteristic (ROC) curves. I would love to have twins but am afraid of the possible complications. Congrats. Slightly: The first HCG level after ivf embryo transfer gives only a rough idea of success. That's wonderful! Press J to jump to the feed. Contact our team on 0161 300 2737. However, this test is not recommend for twin pregnancies (just in case:). Papageorgiou TC, Leondires MP, Miller BT, Chang AS, Armstrong AB, Scott LA, et al. It is used to diagnose pregnancy and a result greater than 5 mIU/mL is generally considered positive. doi: 10.1002/14651858.CD011537.pub2. J Huazhong Univ Sci Technolog Med Sci. Don't obsess. Google Scholar. It has been reported that the rate of vanishing twin syndrome was as high as 10% after ART [13], which may affect the initial maternal serum -hCG level. The influence of other factors: age (patients 20-50), number of transferred embryos (one, two and more) and the length of cultivation on the probability of finishing pregnancy with delivery or loss and the possibility to predict multiple pregnancy was also related to the known hCG value.